Poisoning the Messengers: Could Tumor Endothelial Cells Acquire Drug Resistance
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چکیده
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How Tumor Cells Acquire Resistance to Kinase Inhibitors
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متن کامل[Tumor stem cells and drug resistance].
The tumor stem cells possessing stem cells properties have been described in haematopoietic cancer and some solid tumors. It is believed the regeneration and displace of cancer after chemotherapy have tighten relation with the residual tumor stem cells. The main reason is that tumor stem cells over-express ATP-binding cassette drug transporters and Bcl-2. Moreover, tumor stem cells have the cha...
متن کاملHuman hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells.
PURPOSE Increasing evidence indicates that tumor-derived endothelial cells (TEC) possess a distinct and unique phenotype compared with endothelial cells (NEC) from adjacent normal tissue and may be able to acquire resistance to drugs. The aim of this study was to investigate the angiogenesis activity and response to drug treatment of TECs and NECs derived from human hepatocellular carcinoma (HC...
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In this issue of Clinical Cancer Research, Xiong and colleagues report that isolated tumor-specific endothelial cells (TECs) from human hepatocellular carcinoma (HCC) are less sensitive to cytotoxic and antiangiogenic drugs when compared to their normal counterparts in vitro (1). The results of this study are in good accord with the growing body of in vivo evidence and clinical data suggesting ...
متن کاملTumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance
Tumor blood vessels play an important role in tumor progression and metastasis. We previously reported that tumor endothelial cells (TEC) exhibit several altered phenotypes compared with normal endothelial cells (NEC). For example, TEC have chromosomal abnormalities and are resistant to several anticancer drugs. Furthermore, TEC contain stem cell-like populations with high aldehyde dehydrogenas...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2002
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.79